Is EBV Associated with Breast Cancer in Specific Geographic Locations?

Epstein–Barr virus (EBV) is a that establishes life-long infection in people, and with EBV nearly ubiquitous by adulthood. was identified from biopsy material child Burkitt’s lymphoma (BL) sub-Saharan Africa. has well-characterised role the development of some cancers, notably, (BL), Hodgkin’s disease (HD), gastric carcinoma (GC), nasopharyngeal (NPC). Links have also been made between breast cancer (BC), but these controversial. For all EBV-associated nature EBV, contrasted relatively rare cancer, highlights problem determining whether an aetiological agent cancer. In addition, geographic distributions cancers point to contributions additional co-factors. Recent meta-analyses incidence within BC biopsies revealed diversity conclusions remain, however, they show more association study locations. Here, we review evidence linking BC, conclude for presence concentrated specific regions currently insufficient provide causal link. We pose questions could help resolve question contributes probe contribution might make aetiology BC.